selamectin like drugs used in human and vet medicine

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selamectin like drugs used in human and vet medicine

Postby malernee » Sun Sep 19, 2004 12:30 pm

Dermatol Clin. 2003 Apr;21(2):277-82. Related Articles, Links


Ivermectin.

Elgart GW, Meinking TL.

Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, 1444 North West 9th Avenue, Miami, FL 33136, USA. gelgart@med.miami.edu

Ivermectin is a potent antiparasitic drug and the first commercially available member of a new class of drugs (macrocyclic lactones) that has been approved for human use. Ivermectin has already proven to be highly effective in the elimination of river blindness as a public health burden. Side effects have been minor, and patient acceptance is good. Promising results in off-label applications for ectoparasitic infestations are increasingly important as resistance to topical therapy becomes more prevalent Ivermectin represents an advance in the therapeutic armamentarium and should be considered in appropriate cases.

Publication Types:
Review
Review, Tutorial

PMID: 12757250 [PubMed - indexed for MEDLINE]
malernee
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human trial using selemectin like drugs every three months

Postby malernee » Sun Sep 19, 2004 12:34 pm

1: Lancet. 2002 Jul 20;360(9328):203-10. Related Articles, Links


Comment in:
Lancet. 2002 Jul 20;360(9328):187-95.

Effects of standard and high doses of ivermectin on adult worms of Onchocerca volvulus: a randomised controlled trial.

Gardon J, Boussinesq M, Kamgno J, Gardon-Wendel N, Demanga-Ngangue, Duke BO.

Institut Pasteur de la Guyane, Cayenne Cedex, Guyane Francaise, France.

BACKGROUND: At present, control of onchocerciasis depends almost entirely on yearly treatments with 150 microg/kg ivermectin. We aimed to compare the effect of higher doses, more frequent doses, or both with the standard regimen on adult Onchocerca volvulus. METHODS: We randomly allocated 657 patients who had onchocerciasis to 150 microg/kg ivermectin yearly (reference group), 150 microg/kg every 3 months, 400 then 800 microg/kg yearly, or 400 then 800 microg/kg every 3 months. We took skin snip samples from every patient before, and 3 years and 4 years after the first dose, and, at the same time excised one subcutaneous O volvulus nodule, which was examined histologically. The primary outcome was the vital status of the female worms. Analysis was done per protocol. FINDINGS: We obtained nodules from 511 patients. After 3 years of treatment, more female worms had died in the groups treated every 3 months than in the reference group (odds ratio=1.84 [95% CI 1.23-2.75], p=0.003 for 150 microg/kg; and 2.17 [1.42-3.31], p<0.001 for high doses). Female worms were also less fertile in these groups than in the reference group (0.24 [0.14-0.43], p<0.0001; and 0.14 [0.06-0.29], p<0.0001, respectively). No difference was recorded between groups treated yearly (p=0.83 for the proportion of dead females). Unexpected side-effects consisted of mild, temporary, subjective visual changes in patients on high-dose regimens. INTERPRETATION: Treatment with 3-monthly ivermectin could greatly reduce the number of female worms and acute itching and skin lesions; lower transmission of O volvulus; and change the duration of control programmes.

Publication Types:
Clinical Trial
Multicenter Study
Randomized Controlled Trial

PMID: 12133654 [PubMed - indexed for MEDLINE]
malernee
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Posts: 462
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