immediate-type allergic reactions after vaccination.

Issues involving dog vaccines. Questions, answers, theories, and evidence.
Are annual vaccinations needed, harmful and are they required by law?

immediate-type allergic reactions after vaccination.

Postby malernee » Wed Aug 17, 2005 6:31 pm

IgE reactivity to vaccine components in dogs that developed immediate-type allergic reactions after vaccination.
Vet Immunol Immunopathol 104[3-4]:249-56 2005 Apr 8

Ohmori K, Masuda K, Maeda S, Kaburagi Y, Kurata K, Ohno K, Deboer DJ, Tsujimoto H, Sakaguchi M
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. aa27150@mail.ecc.u-tokyo.ac.jp
Allergic reactions after vaccination are considered as an important practical problem in dogs; however, their immunological mechanism has not been well understood. The present study was designed to investigate the relationship between IgE reactivity to the vaccines and immediate-type allergic reactions after vaccination in dogs. Sera from 10 dogs that developed immediate-type allergic reactions such as circulatory collapse, cyanosis, dyspnea, facial edema, and vomiting within 1h after vaccination with non-rabies monovalent or combined vaccines and sera from 50 dogs that did not develop allergic reactions after vaccination were collected. Serum IgE reactivity to the injected vaccines was measured by fluorometric ELISA using a mouse monoclonal anti-dog IgE antibody. Then, IgE reactivity to fetal calf serum (FCS) and stabilizer proteins (gelatin, casein, and peptone) included in the vaccines was measured in sera that had high levels of IgE to the vaccines. Levels of serum specific IgE to the vaccines in dogs with immediate-type allergic reactions (59-4173 fluorescence units [FU], mean +/- S.D.: 992.5 +/- 1181.9 FU) were significantly higher than those in control dogs (38-192 FU, 92.4 +/- 43.3 FU) (P < 0.001). Of the eight dogs that developed immediate-type allergic reactions and had high levels of serum specific IgE to the vaccines, seven had specific IgE directed to FCS. The IgE reactivity to the vaccines in sera from these dogs was almost completely inhibited by FCS. The other one dog had serum IgE directed to gelatin and casein included in the vaccine as stabilizers. The results obtained in this study suggest that immediate-type allergic reactions after vaccination in dogs were induced by type I hypersensitivity mediated by IgE directed to vaccine components. In addition, FCS, gelatin, and casein included in vaccines could be the causative allergens that induced immediate-type allergic reactions after vaccination in dogs.
malernee
Site Admin
 
Posts: 462
Joined: Wed Aug 13, 2003 5:56 pm

Return to Dog Vaccines

Who is online

Users browsing this forum: Yahoo [Bot] and 1 guest