complete remission cancer study using piroxicam cox 1 and 2

evidence-based cancer treatment — the discipline that insists on proof that time-honored medical practices and procedures are actually effective.
No ancedotal stuff please.
Pet cancer treatment can cost ten thousand USA dollars. This forum is for people to tell us how they were able to obtain cancer treatment when they had no pet health insurance to cover the cost. Rabie Vaccine caused cancer often is paid for by the company that produced the vaccine even when not legally required to do so.

complete remission cancer study using piroxicam cox 1 and 2

Postby guest » Sat Sep 27, 2003 5:46 am

In: Genes, Dogs and Cancer: 3rd Annual Canine Cancer Conference - 2003, Modiano J. F. (Ed.)
International Veterinary Information Service, Ithaca NY (www.ivis.org), 2003; P3002.0903

Clinical Trials in Urinary Bladder Cancer – Translation from Dogs to Humans (Last Updated: 5-Sep-2003 )
D. Knapp1, S. I. Mohammed2, R. S. Foster3, L. Cheng4 and W. R. Widmer5

1,5Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN, USA.
2Department of Veterinary Pathobiology, Purdue University, West Lafayette, IN, USA.
3Department of Urology, Indiana University, Indianapolis, IN, USA.
4Department of Pathology, Indiana University, Indianapolis, IN, USA.

Cancer is a major cause of morbidity and mortality in pet dogs and humans. Approximately 25% of humans and approximately 30% of older dogs in most breeds will develop cancer during their lifetime. Therapy remains ineffective for many forms of cancer. A long standing approach to "find" new cancer therapies for pet animals has been to "adapt" therapies currently in use in humans for use in dogs. While this flow of information from humans to dogs has provided some benefit to pet animals, it may be much more important to pet animals and to humans to design studies in which new information is generated in dogs and then flows from dogs to humans. Our group is pursing this approach in studies of invasive urinary bladder cancer. Naturally-occurring canine transitional cell carcinoma (TCC) of the urinary bladder closely mimics invasive urinary bladder cancer in humans in histopathologic characteristics, biologic behavior, and response (or lack thereof) to therapy. Survival with TCC metastasis is typically less than one year in humans and less than 110 days in dogs. A novel therapy approach for TCC being studied by our group is the use of cyclooxygenase (cox) inhibitors as antitumor agents in TCC. Cox-2 is expressed in the majority of canine and human TCC cases. Single agent piroxicam (which inhibits the activity of cox-1 and cox-2) has been given to 62 dogs with TCC in clinical trials. Tumor responses have included: 2 complete remission, 9 partial remission (>50% reduction in tumor volume), 35 stable disease (<50% change in tumor volume), and 16 progressive disease (>50% increase in tumor volume or new tumor lesions). The remission rate and stable disease rate are as good as or better than those for chemotherapy. These canine studies have led to 2 clinical trials of cox inhibitors in people with urinary bladder cancer at Indiana University (Dr. R. Foster, PI). In one trial, patients with carcinoma in situ (high grade cancer which has not yet invaded) are being treated with piroxicam after failing to respond to traditional medical therapy. Of 5 patients enrolled to date, 2 have had complete remission of their cancer. In a second clinical trial, patients who already have invasive TCC are being treated with a cox-2 inhibitor between diagnosis and cystectomy (cystectomy is standard treatment of invasive TCC in humans). The primary endpoint in this trial, induction of apoptosis (which was selected from canine studies), has been noted in 3 of 5 patients enrolled to date. In conclusion, studies of cox inhibitor therapy in TCC demonstrate how important information gained in canine studies can be of benefit to pet dogs and to humans with cancer. Supported by Morris Animal Foundation and National Institutes of Health.
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