MAST-CELL TUMORS client information and treatment studies

evidence-based cancer treatment — the discipline that insists on proof that time-honored medical practices and procedures are actually effective.
No ancedotal stuff please.
Pet cancer treatment can cost ten thousand USA dollars. This forum is for people to tell us how they were able to obtain cancer treatment when they had no pet health insurance to cover the cost. Rabie Vaccine caused cancer often is paid for by the company that produced the vaccine even when not legally required to do so.

MAST-CELL TUMORS client information and treatment studies

Postby guest » Fri Sep 26, 2003 7:16 pm

MAST-CELL TUMORS

General Information
Mast-cell tumors occur in dogs and cats and may be non-cancerous (benign) or cancerous (malignant). Their cause is unknown, but they occur more frequently in Boxers, Boston Terriers, English Bulldogs, Bull Terriers, Fox Terriers, Labrador Retrievers, Dachshunds, and Weimaraners than in other breeds. Most dogs are middle-aged when affected.
Mast-cell tumors vary widely in shape and size, but they are usually single tumors in dogs and multiple tumors in cats. In dogs, they occur most frequently on the trunk, limbs, and anal region. Malignant mast-cell tumors in dogs are frequently located between the toes.

Important Points in Treatment
1. Mast-cell tumors should be surgically removed as soon as possible because many are malignant.
2. Irradiation and/or chemotherapy are recommended when mast-cell tumors are advanced or cannot be completely removed. The doctor will advise you if your pet should receive this type of therapy.
days.

Prednisone and Vinblastine Chemotherapy for Canine Mast Cell Tumor - 41 Cases (1992-1997)

<<J Vet Intern Med 13[5]:491-497 Sep/Oct'99 Retrospective Study 30 Refs
Douglas H. Thank; Elizabeth A. Mauldin; David M. Vail *
* Dept. of Veterinary Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Dr. West, Madison, WI 53706; e-mail: vaild@svm.vetmed.wisc.edu

Forty-one dogs with mast cell tumors (MCTs) were treated with oral prednisone and injectable vinblastine (VBL), both in the adjuvant setting (23 dogs) and in dogs with gross disease (18 dogs). Adverse effects were noted in 20% (8/41) of the patients, usually after the 1st dose of VBL. Adverse effects were considered mild in 6, and severe, necessitating treatment discontinuation, in 2 (5%). Overall response rate in the evaluable dogs with gross disease was 47% (7/15), consisting of 5 complete responses and 2 partial responses. Median response duration was 154 days (24 to >645 days). As adjuvant therapy to incomplete surgical resection, prednisone and VBL conferred a 57% 1- and 2-year disease-free rate. Median survival time (MST) for the entire patient population was not reached with a median follow-up of 573 days; however, the MST for dogs with grade 111 MCT was 331 days, with 45% of dogs alive at 1 and 2 years. This is an apparent improvement over historical survival data employing surgery alone. Upon univariate analysis, significant prognostic factors (P < .05) for survival included presence of a locally recurrent tumor, presence of gross disease, argyrophilic nucleolar organizer region frequency, lymph node status, histologic grade, previous chemotherapy, and ulceration of the tumor. Similar criteria were significant when analyzed for time to treatment failure. Response to therapy was also predictive of survival in the gross disease group. Upon multivariate analysis, histologic grade (P = .012) and presence of a locally recurrent tumor (P < .001) were significant factors for survival. [author abstract]

Response of Canine Mast Cell Tumors to Treatment With Oral Prednisone

<<J Vet Int Med 8[6]:406-408 Nov/Dec'94 Clinical Study 11 Refs

* Dudley L. McCaw, Margaret A. Miller, Gregory K. Ogilvie, Stephen J. Withrow, William G. Brewer Jr, Mary Kay Klein, Ford W. Bell, and Sharon K. Anderson
*Department of Veterinary Medicine and Surgery, University of Missouri, 379 E Campus Dr, Columbia. MO 65211.


- Twenty-five dogs with naturally occurring mast cell tumors were treated with daily oral prednisone (1 mg/kg) for 28 days. Five dogs (20%) had reduction in tumor volume and were considered responders. Four of these underwent partial remission and one underwent complete remission. Survival times for the five responders were 3, 5, 6, 7.5, and greater than 28 months, respectively. We therefore conclude that prednisone is effective in some canine mast cell tumors. Further studies are indicated to determine the most effective dose of prednisone, the appropriate duration of treatment, and the efficacy in more benign mast cell tumors, and in combination with other forms of therapy. (Author Abstract)

Deionised water as an adjunct to surgery for the treatment of canine cutaneous mast cell tumours.

<<J Small Anim Pract 2000 Jan;41(1):7-11
Jaffe MH, Hosgood G, Kerwin SC, Hedlund CS, Taylor HW
Department of Veterinary Clinical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge 70803, USA.

Medical records of 55 dogs with a diagnosis of cutaneous mast cell tumour were reviewed. Twenty-seven of the dogs were treated with surgery plus deionized water and the remaining 28 with surgery alone. A survival analysis was performed to determine whether deionized water, as an adjunct to surgery for cutaneous mast cell tumour, affected survival time or time to tumour recurrence. Dogs in which mast cell tumour recurred had a significantly shorter survival time compared with dogs with no recurrence (P = 0.05), regardless of the method of treatment. A significant negative association between tumour recurrence and method of treatment (P = 0.0097) and clinical stage (P = 0.0223) was observed. Dogs treated with surgery and deionized water had a significantly shorter time to recurrence of their mast cell tumour (P = 0.0113). Based on these results, deionized water does not appear to be beneficial in prolonging survival time or time to tumour recurrence for dogs with cutaneous mast cell tumours.
guest
 

Return to cancer treatment

Who is online

Users browsing this forum: No registered users and 3 guests

cron